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CATSPER4
Identifiers
Aliases	CATSPER4, CatSper4, cation channel sperm associated 4
External IDs	OMIM: 609121 MGI: 3043288 HomoloGene: 18638 GeneCards: CATSPER4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,202,968 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,954,694 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	378807
	329954
	ENSG00000188782
	ENSMUSG00000048003
	Q7RTX7
	Q8BVN3
	NM_198137
	NM_001130030; NM_177866
	NP_937770
	NP_001123502; NP_808534
	Wikidata
View/Edit Human	View/Edit Mouse

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.^[5]^[6]^[7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188782 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048003 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.
^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.
^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188782 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048003 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12932298-5] Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.

[pmid17227845-6] Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.

[pmid16382101-7] Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.

[IUPHAR-DB-8] *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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