Protein-coding gene in humans
Para-hydroxybenzoate—polyprenyltransferase, mitochondrial is an enzyme that in humans is encoded by the COQ2 gene .[5] [6]
CoQ (ubiquinone ) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004).[supplied by OMIM][6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000173085 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029319 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Forsgren M, Attersand A, Lake S, Grunler J, Swiezewska E, Dallner G, Climent I (Aug 2004). "Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ" . Biochem J . 382 (Pt 2): 519–26. doi :10.1042/BJ20040261 . PMC 1133808 PMID 15153069 . ^ a b "Entrez Gene: COQ2 coenzyme Q2 homolog, prenyltransferase (yeast)" .
External links [ edit ] Further reading [ edit ]
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491–6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Esaka Y, Nagahara Y, Hasome Y, et al. (2005). "Coenzyme Q2 induced p53-dependent apoptosis". Biochim. Biophys. Acta . 1724 (1–2): 49–58. doi :10.1016/j.bbagen.2005.04.013 . PMID 15905035 . Quinzii C, Naini A, Salviati L, et al. (2007). "A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency" . Am. J. Hum. Genet . 78 (2): 345–9. doi :10.1086/500092 . PMC 1380241 PMID 16400613 . Burón MI, Hermán MD, Alcaín FJ, Villalba JM (2006). "Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate". Anal. Biochem . 353 (1): 15–21. doi :10.1016/j.ab.2006.03.029 . PMID 16643834 . González-Aragón D, Burón MI, López-Lluch G, et al. (2006). "Coenzyme Q and the regulation of intracellular steady-state levels of superoxide in HL-60 cells". BioFactors . 25 (1–4): 31–41. doi :10.1002/biof.5520250105 . PMID 16873928 . S2CID 45053711 . Mollet J, Giurgea I, Schlemmer D, et al. (2007). "Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders" . J. Clin. Invest . 117 (3): 765–72. doi :10.1172/JCI29089 . PMC 1804361 PMID 17332895 . López-Martín JM, Salviati L, Trevisson E, et al. (2007). "Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis" . Hum. Mol. Genet . 16 (9): 1091–7. doi :10.1093/hmg/ddm058 . PMC 4345105 PMID 17374725 . Oh J, Ban MR, Miskie BA, et al. (2007). "Genetic determinants of statin intolerance" . Lipids in Health and Disease . 6 : 7. doi :10.1186/1476-511X-6-7 PMC 1832194 PMID 17376224 . Diomedi-Camassei F, Di Giandomenico S, Santorelli FM, et al. (2007). "COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement" . J. Am. Soc. Nephrol . 18 (10): 2773–80. doi :10.1681/ASN.2006080833 PMID 17855635 .
