This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[6][7] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[8] The gene for CCL27 is located on human chromosome 9.[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].
^Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
^Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (November 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters. 460 (3): 544–8. doi:10.1016/s0014-5793(99)01406-4. PMID10556532. S2CID39019419.
Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, et al. (March 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". The Journal of Allergy and Clinical Immunology. 111 (3): 592–7. doi:10.1067/mai.2003.114. PMID12642842.
Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (January 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine. 29 (2): 49–55. doi:10.1016/j.cyto.2004.09.008. PMID15598438.
Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, et al. (February 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Experimental Dermatology. 14 (2): 109–16. doi:10.1111/j.0906-6705.2005.00226.x. PMID15679580. S2CID8770112.
Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, et al. (February 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Experimental Dermatology. 15 (2): 95–100. doi:10.1111/j.1600-0625.2005.00390.x. PMID16433680. S2CID31590665.
