Mammalian protein found in Homo sapiens
Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene .[5]
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine , the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract .[5]
References [ edit ] External links [ edit ] Further reading [ edit ]
Johnson MR, Barnes S, Kwakye JB, Diasio RB (1991). "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver" . J. Biol. Chem . 266 (16): 10227–33. doi :10.1016/S0021-9258(18)99213-6 PMID 2037576 . Falany CN, Johnson MR, Barnes S, Diasio RB (1994). "Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase" . J. Biol. Chem . 269 (30): 19375–9. doi :10.1016/S0021-9258(17)32178-6 PMID 8034703 . Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics . 38 (2): 199–205. doi :10.1006/geno.1996.0616 . PMID 8954802 . Solaas K, Ulvestad A, Söreide O, Kase BF (2000). "Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts" . J. Lipid Res . 41 (7): 1154–62. doi :10.1016/S0022-2275(20)32022-8 PMID 10884298 . Sfakianos MK, Wilson L, Sakalian M, et al. (2003). "Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase" . J. Biol. Chem . 277 (49): 47270–5. doi :10.1074/jbc.M207463200 PMID 12239217 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Carlton VE, Harris BZ, Puffenberger EG, et al. (2003). "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT". Nat. Genet . 34 (1): 91–6. doi :10.1038/ng1147 . PMID 12704386 . S2CID 21900697 . Wang H, Tamba M, Kimata M, et al. (2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem. Biophys. Res. Commun . 305 (3): 611–8. doi :10.1016/S0006-291X(03)00808-8 . PMID 12763038 . O'Byrne J, Hunt MC, Rai DK, et al. (2003). "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine" . J. Biol. Chem . 278 (36): 34237–44. doi :10.1074/jbc.M300987200 PMID 12810727 . Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74. Bibcode :2004Natur.429..369H . doi :10.1038/nature02465 . PMC 2734081 PMID 15164053 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Pellicoro A, van den Heuvel FA, Geuken M, et al. (2007). "Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport" . Hepatology . 45 (2): 340–8. doi :10.1002/hep.21528 PMID 17256745 . S2CID 6163420 . Tougou K, Fukuda T, Ito T, et al. (2007). "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals". Drug Metab. Pharmacokinet . 22 (2): 125–8. doi :10.2133/dmpk.22.125 . PMID 17495420 .
