AM-087

AM-087
AM-087.png
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC23H33BrO2
Molar mass421.419 g·mol−1
3D model (JSmol)
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AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoid agonist.[1] It is a derivative of Δ8-THC, substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43 nM, making it around 100 times more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[2]

See also[edit]

References[edit]

  1. ^ Martin, Billy R.; Compton, David R.; Semus, Simon F.; Lin, Sonyuan; Marciniak, Gilbert; Grzybowska, Jolanta; Charalambous, Avgui; Makriyannis, Alexandros (1993). "Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC". Pharmacology Biochemistry and Behavior. 46 (2): 295–301. doi:10.1016/0091-3057(93)90356-X.
  2. ^ Charalambous, A.; Lin, S.; Marciniak, G.; Banijamali, A.; Friend, F. L.; Compton, D. R.; Martin, B. R.; Makriyannis, A. (1991). "Pharmacological evaluation of halogenated delta 8-THC analogs". Pharmacology, Biochemistry, and Behavior. 40 (3): 509–12. doi:10.1016/0091-3057(91)90355-6. PMID 1666915.