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| Names | |
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| IUPAC name
9-[(1S,5R)-8-azabicyclo[3.2.1]octan-3-ylidene]-N,N-diethylxanthene-3-carboxamide
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C25H28N2O2 | |
| Molar mass | 388.511 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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JNJ-20788560 is a potent opioid drug selective for the delta opioid receptor.[2]
Mechanism of action[edit]
It works by activating opioid receptors, but it is selective for the Δ-opioid receptor. This selectivity allows this drug to have less side effects than opioids such as Morphine.
Tests have revealed that JNJ-20788560 did not produce hypoventilation, tolerance and physical dependence.[3]
References[edit]
- ^ "9-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide".
- ^ Codd, Ellen E.; Ma, Jianya; Zhang, Sui-Po; Stone, Dennis J.; Colburn, Raymond W.; Brandt, Michael R.; Chevalier, Kristen M.; Zhu, Yongxin; Peng, Sean; Cai, Chaozhong; Acton, Paul D.; Flores, Christopher M. (August 2010). "Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range". Pharmacology, Biochemistry, and Behavior. 96 (2): 130–135. doi:10.1016/j.pbb.2010.04.020. ISSN 1873-5177. PMID 20438745. S2CID 5471813.
- ^ Codd, Ellen E.; Carson, John R.; Colburn, Raymond W.; Stone, Dennis J.; Van Besien, Christopher R.; Zhang, Sui-Po; Wade, Paul R.; Gallantine, Elizabeth L.; Meert, Theo F.; Molino, Lory; Pullan, Shirley; Razler, Christine M.; Dax, Scott L.; Flores, Christopher M. (April 2009). "JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence". The Journal of Pharmacology and Experimental Therapeutics. 329 (1): 241–251. doi:10.1124/jpet.108.146969. ISSN 1521-0103. PMID 19151246. S2CID 15119165.