THC Science

TB-21007
Identifiers
	IUPAC name 6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one;
CAS Number	207306-50-1 ;
PubChem CID	6918633;
ChemSpider	5293826 ;
UNII	VL2NQQ83RN;
ChEMBL	ChEMBL17603 ;
CompTox Dashboard (EPA)	DTXSID40426083 ;
Chemical and physical data
Formula	C15H17NO2S3
Molar mass	339.49 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES s3ccnc3-c2sc(SCCO)c1c2CC(C)(C)CC1=O;
	InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 ; Key:QILRYFCEXLFIDS-UHFFFAOYSA-N ;
	(what is this?) (verify)

TB-21007 is a nootropic drug which acts as a subtype-selective inverse agonist at the α₅ containing GABA_A receptors.^[1]^[2]

References[edit]

^ Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, et al. (March 2002). "6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists". Journal of Medicinal Chemistry. 45 (6): 1176–9. doi:10.1021/jm010471b. PMID 11881985.
^ Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, et al. (May 2003). "Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition". Journal of Medicinal Chemistry. 46 (11): 2227–40. doi:10.1021/jm020582q. PMID 12747794.

Identifiers


IUPAC name 6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one
CAS Number	207306-50-1^Y
PubChem CID	6918633
ChemSpider	5293826^N
UNII	VL2NQQ83RN
ChEMBL	ChEMBL17603^N
CompTox Dashboard (EPA)	DTXSID40426083
Chemical and physical data
Formula	C₁₅H₁₇NO₂S₃
Molar mass	339.49 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES s3ccnc3-c2sc(SCCO)c1c2CC(C)(C)CC1=O
InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3^N Key:QILRYFCEXLFIDS-UHFFFAOYSA-N^N
^NY (what is this?) (verify)