The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1gene.[5]
The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.[6]
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Sardet C, Franchi A, Pouysségur J (January 1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell. 56 (2): 271–80. doi:10.1016/0092-8674(89)90901-X. PMID2536298. S2CID2782563.
Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenetics and Cell Genetics. 48 (1): 6–8. doi:10.1159/000132575. PMID2846238.
Counillon L, Pouysségur J, Reithmeier RA (August 1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry. 33 (34): 10463–9. doi:10.1021/bi00200a030. PMID8068684.
Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Molecular and Cellular Biochemistry. 125 (2): 137–43. doi:10.1007/BF00936442. PMID8283968. S2CID24360200.