Protein-coding gene in the species Homo sapiens
Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene .[5] [6]
Retrovirus receptors allow infection of human and murine cells by various retroviruses . The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus , Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter .[supplied by OMIM][6]
Research [ edit ] It was reported that mutations of the gene may cause epispadias or bladder exstrophy .[7]
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000144136 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027397 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD (Aug 1994). "Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters" . Proc Natl Acad Sci U S A . 91 (15): 7071–5. Bibcode :1994PNAS...91.7071K . doi :10.1073/pnas.91.15.7071 PMC 44340 PMID 8041748 . ^ a b "Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1" .^ Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, et al. (2020). "SLC20A1 Is Involved in Urinary Tract and Urorectal Development" . Frontiers in Cell and Developmental Biology . 8 : 567. doi :10.3389/fcell.2020.00567 PMC 7426641 PMID 32850778 .
Further reading [ edit ]
Takeuchi Y, Vile RG, Simpson G, et al. (1992). "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus" . J. Virol . 66 (2): 1219–22. doi :10.1128/JVI.66.2.1219-1222.1992 . PMC 240831 PMID 1309898 . Johann SV, Gibbons JJ, O'Hara B (1992). "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus" . J. Virol . 66 (3): 1635–40. doi :10.1128/JVI.66.3.1635-1640.1992 . PMC 240899 PMID 1531369 . Kaelbling M, Eddy R, Shows TB, et al. (1991). "Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2" . J. Virol . 65 (4): 1743–7. doi :10.1128/JVI.65.4.1743-1747.1991 . PMC 239979 PMID 1672162 . O'Hara B, Johann SV, Klinger HP, et al. (1991). "Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus". Cell Growth Differ . 1 (3): 119–27. PMID 2078500 . Olah Z, Lehel C, Anderson WB, et al. (1994). "The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter" . J. Biol. Chem . 269 (41): 25426–31. doi :10.1016/S0021-9258(18)47267-5 PMID 7929240 . Miller DG, Miller AD (1994). "A family of retroviruses that utilize related phosphate transporters for cell entry" . J. Virol . 68 (12): 8270–6. doi :10.1128/JVI.68.12.8270-8276.1994 . PMC 237294 PMID 7966619 . Johann SV, van Zeijl M, Cekleniak J, O'Hara B (1993). "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species" . J. Virol . 67 (11): 6733–6. doi :10.1128/JVI.67.11.6733-6736.1993 . PMC 238113 PMID 8411375 . Tatsumi S, Segawa H, Morita K, et al. (1998). "Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands" . Endocrinology . 139 (4): 1692–9. doi :10.1210/endo.139.4.5925 PMID 9528951 . Palmer G, Manen D, Bonjour JP, Caverzasio J (1999). "Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region". Gene . 226 (1): 25–33. doi :10.1016/S0378-1119(98)00572-1 . PMID 9889306 . Jono S, McKee MD, Murry CE, et al. (2000). "Phosphate regulation of vascular smooth muscle cell calcification" . Circ. Res . 87 (7): E10–7. doi :10.1161/01.RES.87.7.e10 PMID 11009570 . Farrell KB, Russ JL, Murthy RK, Eiden MV (2002). "Reassessing the role of region A in Pit1-mediated viral entry" . J. Virol . 76 (15): 7683–93. doi :10.1128/JVI.76.15.7683-7693.2002 . PMC 136385 PMID 12097582 . Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function" . J. Biol. Chem . 277 (45): 42741–7. doi :10.1074/jbc.M207096200 PMID 12205090 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways" . Oncogene . 22 (21): 3307–18. doi :10.1038/sj.onc.1206406 PMID 12761501 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R (2005). "Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes" . Arthritis Rheum . 52 (1): 144–54. doi :10.1002/art.20748 PMID 15641067 . Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31. Bibcode :2005Natur.434..724H . doi :10.1038/nature03466 PMID 15815621 . Li X, Yang HY, Giachelli CM (2006). "Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification" . Circ. Res . 98 (7): 905–12. doi :10.1161/01.RES.0000216409.20863.e7 PMID 16527991 . Bøttger P, Hede SE, Grunnet M, et al. (2007). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2". Am. J. Physiol., Cell Physiol . 291 (6): C1377–87. doi :10.1152/ajpcell.00015.2006 . PMID 16790504 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
By group
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