Protein-coding gene in the species Homo sapiens
5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene .[5] [6]
The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK ). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP /ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation . It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]
Interactions [ edit ]
Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2 .[7] [8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000132356 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050697 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily" . J Biol Chem . 271 (2): 611–4. doi :10.1074/jbc.271.2.611 . PMID 8557660 .
^ a b "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit" .
^ Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival" . Cell . 115 (5). United States: 577–90. doi :10.1016/S0092-8674(03)00929-2 . ISSN 0092-8674 . PMID 14651849 . S2CID 18173817 .
^ Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling" . Cancer Cell . 6 (1). United States: 91–9. doi :10.1016/j.ccr.2004.06.007 . ISSN 1535-6108 . PMID 15261145 .
Further reading [ edit ]
Munday MR, Campbell DG, Carling D, Hardie DG (1988). "Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase" . Eur. J. Biochem . 175 (2): 331–8. doi :10.1111/j.1432-1033.1988.tb14201.x . PMID 2900138 .
Woods A, Cheung PC, Smith FC, et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro" . J. Biol. Chem . 271 (17): 10282–90. doi :10.1074/jbc.271.48.30517 . PMID 8626596 .
Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase" . J. Biol. Chem . 271 (44): 27879–87. doi :10.1074/jbc.271.44.27879 . PMID 8910387 .
Stapleton D, Woollatt E, Mitchelhill KI, et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location". FEBS Lett . 409 (3): 452–6. doi :10.1016/S0014-5793(97)00569-3 . PMID 9224708 . S2CID 39329574 .
Velasco G, Gómez del Pulgar T, Carling D, Guzmán M (1998). "Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components" . FEBS Lett . 439 (3): 317–20. doi :10.1016/S0014-5793(98)01400-8 . PMID 9845345 . S2CID 29493620 .
Crute BE, Seefeld K, Gamble J, et al. (1999). "Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase" . J. Biol. Chem . 273 (52): 35347–54. doi :10.1074/jbc.273.52.35347 . PMID 9857077 .
da Silva Xavier G, Leclerc I, Salt IP, et al. (2000). "Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression" . Proc. Natl. Acad. Sci. U.S.A . 97 (8): 4023–8. Bibcode :2000PNAS...97.4023D . doi :10.1073/pnas.97.8.4023 . PMC 18135 . PMID 10760274 .
Hallows KR, Raghuram V, Kemp BE, et al. (2000). "Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase" . J. Clin. Invest . 105 (12): 1711–21. doi :10.1172/JCI9622 . PMC 378514 . PMID 10862786 .
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 . PMID 11042152 .
Chen ZP, McConell GK, Michell BJ, et al. (2000). "AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation". Am. J. Physiol. Endocrinol. Metab . 279 (5): E1202–6. doi :10.1152/ajpendo.2000.279.5.E1202 . PMID 11052978 . S2CID 13387968 .
Blázquez C, Geelen MJ, Velasco G, Guzmán M (2001). "The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes" . FEBS Lett . 489 (2–3): 149–53. doi :10.1016/S0014-5793(01)02089-0 . PMID 11165240 . S2CID 35584617 .
Diggle TA, Subkhankulova T, Lilley KS, et al. (2001). "Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity" . Biochem. J . 353 (Pt 3): 621–6. doi :10.1042/0264-6021:3530621 . PMC 1221608 . PMID 11171059 .
Wang X, Li W, Williams M, et al. (2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase" . EMBO J . 20 (16): 4370–9. doi :10.1093/emboj/20.16.4370 . PMC 125559 . PMID 11500364 .
Xi X, Han J, Zhang JZ (2001). "Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase" . J. Biol. Chem . 276 (44): 41029–34. doi :10.1074/jbc.M102824200 . PMID 11546797 .
Fryer LG, Foufelle F, Barnes K, et al. (2002). "Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells" . Biochem. J . 363 (Pt 1): 167–74. doi :10.1042/0264-6021:3630167 . PMC 1222463 . PMID 11903059 .
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys . 400 (1): 105–10. doi :10.1006/abbi.2002.2778 . PMID 11913976 .
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling" . J. Biol. Chem . 277 (27): 23977–80. doi :10.1074/jbc.C200171200 . PMID 11997383 .
Esumi H, Izuishi K, Kato K, et al. (2002). "Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner" . J. Biol. Chem . 277 (36): 32791–8. doi :10.1074/jbc.M112270200 . PMID 12091379 .
Horman S, Browne G, Krause U, et al. (2003). "Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis" . Curr. Biol . 12 (16): 1419–23. doi :10.1016/S0960-9822(02)01077-1 . PMID 12194824 . S2CID 9865400 .
External links [ edit ]
PDBe-KB provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Activity Regulation Classification Kinetics Types