Protein-coding gene in the species Homo sapiens
PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene .[5] [6] [7] [8]
PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast , flies , and mammals .[supplied by OMIM][8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000115687 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026274 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors" (PDF) . Biochem Biophys Res Commun . 288 (4): 757–64. doi :10.1006/bbrc.2001.5840 . PMID 11688972 . Archived from the original (PDF) on 2013-11-02. Retrieved 2018-12-22 . ^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase" . Proc Natl Acad Sci U S A . 98 (16): 8991–6. Bibcode :2001PNAS...98.8991R . doi :10.1073/pnas.161284798 PMC 55361 PMID 11459942 . ^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose" . Proc Natl Acad Sci U S A . 101 (22): 8319–24. Bibcode :2004PNAS..101.8319D . doi :10.1073/pnas.0307737101 PMC 420392 PMID 15148392 . ^ a b "Entrez Gene: PASK PAS domain containing serine/threonine kinase" .
Further reading [ edit ]
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones" (PDF) . DNA Res . 9 (3): 99–106. doi :10.1093/dnares/9.3.99 PMID 12168954 . Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 2 (4): 167–74, 199–210. doi :10.1093/dnares/2.4.167 PMID 8590280 . Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Ceulemans H, Van Eynde A, Pérez-Callejón E, et al. (1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1" . Eur. J. Biochem . 262 (1): 36–42. doi :10.1046/j.1432-1327.1999.00344.x PMID 10231361 . Amezcua CA, Harper SM, Rutter J, Gardner KH (2003). "Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation" . Structure . 10 (10): 1349–61. doi :10.1016/S0969-2126(02)00857-2 PMID 12377121 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Eckhardt K, Troger J, Reissmann J, et al. (2007). "Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1" . Cell. Physiol. Biochem . 20 (1–4): 227–40. doi :10.1159/000104169 PMID 17595531 . Kikani CK, Antonysamy SA, Bonanno JB, et al. (2010). "Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation" . J. Biol. Chem . 285 (52): 41034–43. doi :10.1074/jbc.M110.157594 PMC 3003402 PMID 20943661 .
Activity Regulation Classification Kinetics Types
