Protein-coding gene in the species Homo sapiens
P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene .[5] [6] [7]
The product of this gene belongs to the family of purinoceptors for ATP . This receptor functions as a cation conducting ligand-gated ion channel . Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000187848 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029503 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol . 56 (6): 1171–81. doi :10.1124/mol.56.6.1171 . PMID 10570044 . ^ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature . 371 (6497): 519–23. Bibcode :1994Natur.371..519B . doi :10.1038/371519a0 . PMID 7523952 . S2CID 4371044 . ^ a b "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2" .
Further reading [ edit ]
North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev . 82 (4): 1013–67. doi :10.1152/physrev.00015.2002 . PMID 12270951 . Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize" . J. Biol. Chem . 280 (11): 10759–65. doi :10.1074/jbc.M412265200 PMID 15657042 . Mason HS, Bourke S, Kemp PJ (2005). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species". Mol. Pharmacol . 66 (6): 1525–35. doi :10.1124/mol.104.000851 . PMID 15331767 . S2CID 24536809 . Aschrafi A, Sadtler S, Niculescu C, et al. (2004). "Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes". J. Mol. Biol . 342 (1): 333–43. doi :10.1016/j.jmb.2004.06.092 . PMID 15313628 . Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels" . J. Biol. Chem . 279 (8): 6967–75. doi :10.1074/jbc.M307772200 PMID 14660627 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Järlebark LE, Housley GD, Raybould NP, et al. (2003). "ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea". NeuroReport . 13 (15): 1979–84. doi :10.1097/00001756-200210280-00030 . PMID 12395104 . S2CID 10991307 . Khakh BS, Zhou X, Sydes J, et al. (2000). "State-dependent cross-inhibition between transmitter-gated cation channels" (PDF) . Nature . 406 (6794): 405–10. Bibcode :2000Natur.406..405K . doi :10.1038/35019066 . PMID 10935636 . S2CID 4500837 . Brändle U, Spielmanns P, Osteroth R, et al. (1997). "Desensitization of the P2X(2) receptor controlled by alternative splicing" . FEBS Lett . 404 (2–3): 294–8. doi :10.1016/S0014-5793(97)00128-2 PMID 9119082 . S2CID 39951168 . Lewis C, Neidhart S, Holy C, et al. (1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons". Nature . 377 (6548): 432–5. Bibcode :1995Natur.377..432L . doi :10.1038/377432a0 . PMID 7566120 . S2CID 4361850 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
