THC Science

KLF8
Identifiers
Aliases	KLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDs	OMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8
Gene location (Human)
Chr.	X chromosome (human)
End	56,291,531 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	152,179,128 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	11279
	245671
	ENSG00000102349
	ENSMUSG00000041649
	O95600
	Q8BLM0
NM_001159296; NM_007250; NM_001324099; NM_001324100; NM_001324102;
	NM_001324104; NM_001324105
	NM_173780; NM_001357183
NP_001152768; NP_001311028; NP_001311029; NP_001311031; NP_001311033;
	NP_001311034; NP_009181
	NP_776141; NP_001344112
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.^[5] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.^[6]

Interactions[edit]

KLF8 has been shown to interact with CTBP2.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KLF8 Kruppel-like factor 8".
^ Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.
^ van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

Further reading[edit]

van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.
Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L (Feb 2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation". Journal of Medical Genetics. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMC 1735036. PMID 11836360.
Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (Apr 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (Jun 2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell. 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.
Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
Wang X, Zhao J (Jan 2007). "KLF8 transcription factor participates in oncogenic transformation". Oncogene. 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.
Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ (Mar 2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation". Journal of Molecular Biology. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMC 1907364. PMID 17224162.
Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (Aug 2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.

External links[edit]

KLF8 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KLF8 Kruppel-like factor 8".

[molecular_and_cell_biology-6] Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.

[pmid10756197-7] van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

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