JZL195

JZL195
JZL195 molecular structure.png
Names
IUPAC name

(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Identifiers
3D model (JSmol)
ChemSpider
Properties
C24H23N3O5
Molar mass 433.457
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.[1]

See also[edit]

References[edit]

  1. ^ Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF (December 2009). “Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo”. Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20270–5. doi:10.1073/pnas.0909411106. PMC 2787168. PMID 19918051.