Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4gene.[5][6][7][8]
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.[8]
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Tu N, Hu Y, Mivechi NF (2006). "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins". J. Cell. Biochem. 98 (6): 1528–42. doi:10.1002/jcb.20865. PMID16552721. S2CID36553127.
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