Human protein-coding gene
GTF2E1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VD4 , 2JTX , 2RNQ , 2RNR , 5IY9 , 5IYC , 5IYD , 5IY7 , 5IYA , 5IY6 , 5IYB , 5IY8
Identifiers Aliases GTF2E1 External IDs OMIM : 189962 MGI : 1921447 HomoloGene : 38062 GeneCards : GTF2E1 Wikidata
General transcription factor IIE subunit 1 (GTF2E1 ), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene .[5]
See also [ edit ] References [ edit ] Further reading [ edit ]
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B (July 2007). "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme" . Molecular Cell . 27 (2): 262–74. doi :10.1016/j.molcel.2007.06.027 . PMC 4498903 PMID 17643375 . Langelier MF, Forget D, Rojas A, Porlier Y, Burton ZF, Coulombe B (October 2001). "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II" . The Journal of Biological Chemistry . 276 (42): 38652–7. doi :10.1074/jbc.M106422200 PMC 4492724 PMID 11509574 . Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A (January 2009). "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study". Gynecologic Oncology . 112 (1): 210–4. doi :10.1016/j.ygyno.2008.09.012 . PMID 18950845 . Yamamoto S, Watanabe Y, van der Spek PJ, Watanabe T, Fujimoto H, Hanaoka F, Ohkuma Y (January 2001). "Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation" . Molecular and Cellular Biology . 21 (1): 1–15. doi :10.1128/MCB.21.1.1-15.2001 . PMC 86563 PMID 11113176 . Watanabe T, Hayashi K, Tanaka A, Furumoto T, Hanaoka F, Ohkuma Y (April 2003). "The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II" . Molecular and Cellular Biology . 23 (8): 2914–26. doi :10.1128/mcb.23.8.2914-2926.2003 . PMC 152561 PMID 12665589 . Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A (May 2006). "Structure and oligomeric state of human transcription factor TFIIE" . EMBO Reports . 7 (5): 500–5. doi :10.1038/sj.embor.7400663 . PMC 1479554 PMID 16547462 . Orphanides G, Lagrange T, Reinberg D (November 1996). "The general transcription factors of RNA polymerase II" . Genes & Development . 10 (21): 2657–83. doi :10.1101/gad.10.21.2657 PMID 8946909 . Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO" . The Journal of Biological Chemistry . 273 (42): 27593–601. doi :10.1074/jbc.273.42.27593 PMID 9765293 . Kim TK, Ebright RH, Reinberg D (May 2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science . 288 (5470): 1418–22. Bibcode :2000Sci...288.1418K . doi :10.1126/science.288.5470.1418 . PMID 10827951 . Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6" . Molecular and Cellular Biology . 18 (1): 10–8. doi :10.1128/mcb.18.1.10 . PMC 121442 PMID 9418848 . Yu X, Li P, Roeder RG, Wang Z (July 2001). "Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split" . Molecular and Cellular Biology . 21 (14): 4614–25. doi :10.1128/MCB.21.14.4614-4625.2001 . PMC 87125 PMID 11416139 . Di Lello P, Miller Jenkins LM, Mas C, Langlois C, Malitskaya E, Fradet-Turcotte A, Archambault J, Legault P, Omichinski JG (January 2008). "p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH" . Proceedings of the National Academy of Sciences of the United States of America . 105 (1): 106–11. Bibcode :2008PNAS..105..106D . doi :10.1073/pnas.0707892105 PMC 2224167 PMID 18160537 . Liu L, Ishihara K, Ichimura T, Fujita N, Hino S, Tomita S, Watanabe S, Saitoh N, Ito T, Nakao M (February 2009). "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity" . The Journal of Biological Chemistry . 284 (8): 5165–74. doi :10.1074/jbc.M807098200 PMID 19106100 . Okamoto T, Yamamoto S, Watanabe Y, Ohta T, Hanaoka F, Roeder RG, Ohkuma Y (July 1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit" . The Journal of Biological Chemistry . 273 (31): 19866–76. doi :10.1074/jbc.273.31.19866 PMID 9677423 . Okuda M, Tanaka A, Arai Y, Satoh M, Okamura H, Nagadoi A, Hanaoka F, Ohkuma Y, Nishimura Y (December 2004). "A novel zinc finger structure in the large subunit of human general transcription factor TFIIE" . The Journal of Biological Chemistry . 279 (49): 51395–403. doi :10.1074/jbc.M404722200 PMID 15385556 . Okuda M, Tanaka A, Satoh M, Mizuta S, Takazawa M, Ohkuma Y, Nishimura Y (April 2008). "Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH" . The EMBO Journal . 27 (7): 1161–71. doi :10.1038/emboj.2008.47 . PMC 2275666 PMID 18354501 . Fraser RA, Heard DJ, Adam S, Lavigne AC, Le Douarin B, Tora L, Losson R, Rochette-Egly C, Chambon P (June 1998). "The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors" . The Journal of Biological Chemistry . 273 (26): 16199–204. doi :10.1074/jbc.273.26.16199 PMID 9632676 . Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y (March 2010). "An atlas of combinatorial transcriptional regulation in mouse and man" . Cell . 140 (5): 744–52. doi :10.1016/j.cell.2010.01.044 . PMC 2836267 PMID 20211142 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
