GATA transcription factors are a family of transcription factors characterized by their ability to bind to the DNA sequence "GATA".[1]
GATA transcription factors have been correlated to their broader influence on stem cell development. Findings however, have pointed to a more direct influence by GATA transcription factors, as they are salient components in the more concentrated regulation of gene expression. Data points to the roles GATA transcription factors play in stages past early development in endocrine organs.[2]
Despite GATA’s influence on endocrine organs and cell development, they have a complex relation to the development and growth of breast cancer. Its immediate influence is not yet known, its high risk for mutation however, makes determining the immediate influence of paramount importance in battling breast cancer.[3]
Some research that has been done on the GATA transcription factor for its role in the development of breast cancer suggests that a specific GATA transcription factor GATA3 can actually inhibit further growth of breast cancer cells.[4] The complete mechanism in which this happens is still not clear.[4] However, research has suggested that the GATA transcription factor creates an unfavorable chemical environment for the breast cancer tumor cells which inhibits the progression of these cells.[4] One way that has been suggested is that the GATA transcription factor lowers the level of adenosine triphosphate (ATP) in the cell.[4] This creates an unfavorable chemical environment for the breast cancer cells because usually they require high levels of ATP to survive.[4] In addition, research has suggested that there is a specific gene called the TRP1 that is expressed in breast cancer cells and the GATA3 transcription factor plays a role in regulating this gene.[5]
Genes[edit]
In humans:
- GATA1 (see also GATA1)
- GATA2 (see also GATA2)
- GATA3 (see also GATA3)
- GATA4 (see also GATA4)
- GATA5 (see also GATA5)
- GATA6 (see also GATA6)
In yeast:
References[edit]
- ^ Ko LJ, Engel JD (July 1993). "DNA-binding specificities of the GATA transcription factor family". Molecular and Cellular Biology. 13 (7): 4011–4022. doi:10.1128/mcb.13.7.4011. PMC 359950. PMID 8321208.
- ^ Viger RS, Guittot SM, Anttonen M, Wilson DB, Heikinheimo M (April 2008). "Role of the GATA family of transcription factors in endocrine development, function, and disease". Molecular Endocrinology. 22 (4): 781–798. doi:10.1210/me.2007-0513. PMC 2276466. PMID 18174356.
- ^ Du F, Yuan P, Wang T, Zhao J, Zhao Z, Luo Y, Xu B (November 2015). "The Significance and Therapeutic Potential of GATA3 Expression and Mutation in Breast Cancer: A Systematic Review". Medicinal Research Reviews. 35 (6): 1300–1315. doi:10.1002/med.21362. PMID 26313026. S2CID 11668034.
- ^ a b c d e Li M, Qi Y, Chen M, Wang Z, Zeng D, Xiao Y, et al. (2019). "GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3". International Journal of Biological Sciences. 15 (12): 2522–2537. doi:10.7150/ijbs.35563. PMC 6854379. PMID 31754326.
- ^ Chen JQ, Bao Y, Lee J, Murray JL, Litton JK, Xiao L, et al. (October 2013). "Prognostic value of the trichorhinophalangeal syndrome-1 (TRPS-1), a GATA family transcription factor, in early-stage breast cancer". Annals of Oncology. 24 (10): 2534–2542. doi:10.1093/annonc/mdt190. PMC 3784330. PMID 23729783.
External links[edit]
- GATA+transcription+factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)