THC Science

FOXN3
Identifiers
Aliases	FOXN3, C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628 HomoloGene: 3809 GeneCards: FOXN3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	89,619,149 bp
RNA expression pattern
	Top expressed in
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	1112
	n/a
	ENSG00000053254
	n/a
	O00409
	n/a
	NM_005197; NM_001085471
	n/a
	NP_001078940; NP_005188
	n/a
	Wikidata
View/Edit Human

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.^[3]^[4]

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.^[4]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000053254 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. doi:10.1128/MCB.17.6.3037. PMC 232156. PMID 9154802.
^ ^a ^b "Entrez Gene: CHES1 checkpoint suppressor 1".

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31". Genomics. 33 (1): 1–8. doi:10.1006/geno.1996.0153. PMID 8617492.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor". Gene. 359: 119–26. doi:10.1016/j.gene.2005.06.014. PMID 16102918.
Busygina V, Kottemann MC, Scott KL, et al. (2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response". Cancer Res. 66 (17): 8397–403. doi:10.1158/0008-5472.CAN-06-0061. PMID 16951149.
Katoh H, Ojima H, Kokubu A, et al. (2007). "Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets". Gastroenterology. 133 (5): 1475–86. doi:10.1053/j.gastro.2007.08.038. PMID 17983802.

External links[edit]

CHES1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000053254 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9154802-3] Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. doi:10.1128/MCB.17.6.3037. PMC 232156. PMID 9154802.

[entrez-4] "Entrez Gene: CHES1 checkpoint suppressor 1".

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[2]

[3]

[4]

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