Demoxepam

Demoxepam
Demoxepam.svg
Pharmacokinetic data
Elimination half-life 35–40 hours
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.012.287 Edit this at Wikidata
Chemical and physical data
Formula C15H11ClN2O2
Molar mass 286.713 g·mol−1
3D model (JSmol)
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Demoxepam[1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties[2][3] and presumably other characteristic benzodiazepine properties.

Synthesis[edit]

Demoxepam is also an intermediate in the synthesis of oxazepam; it is also used in one of the syntheses of medazepam. It can be considered directly analogous/synonoymous with the synthesis of chlordiazepoxide, with the exception that instead of methylamine, hydroxide ion is the choice of base; here acid is not used for the cyclodehydration step though.

Demoxepam synthesis: Reeder Earl, Sternbach Leo Henryk, U.S. Patent 3,136,815 (1959 to Hoffmann La Roche).

See also[edit]

References[edit]

  1. ^ US Patent 3136815
  2. ^ “nortetrazepam”. psychotropics.dk. 2003. Retrieved 7 December 2009.
  3. ^ “LIST OF INTERNATIONAL NON-PROPRIETARY NAMES (INNS), PROVIDED FOR PHARMACEUTICAL SUBSTANCES BY THE WORLD HEALTH ORGANIZATION, WHICH ARE FREE OF DUTY” (PDF). Official Journal of the European Communities. eur-lex.europa.eu. 23 October 2001. Retrieved 7 December 2009.