CUMYL-PEGACLONE

CUMYL-PEGACLONE
CUMYL-PEGACLONE structure.png
Legal status
Legal status
Identifiers
CAS Number
Chemical and physical data
Formula C25H28N2O
Molar mass 372.5 g·mol−1
3D model (JSmol)

CUMYL-PEGACLONE (SGT-151) is a gamma-carboline based synthetic cannabinoid that has been sold as a designer drug.[1][2][3] The gamma-carboline core structure seen in CUMYL-PEGACLONE had not previously been encountered in a designer cannabinoid, though it is similar in structure to other gamma-carboline cannabinoids disclosed by Bristol-Myers Squibb in 2001.[4][5]

See also[edit]

References[edit]

  1. ^ Ernst L, Brandhorst K, Papke U, Altrogge A, Zodel S, Langer N, Beuerle T (August 2017). “Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: Update of the German situation in early 2017”. Forensic Science International. 277: 51–58. doi:10.1016/j.forsciint.2017.05.019. PMID 28601726.
  2. ^ Angerer V, Mogler L, Steitz JP, Bisel P, Hess C, Schoeder CT, Müller CE, Huppertz LM, Westphal F, Schäper J, Auwärter V (July 2017). “Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL-PEGACLONE”. Drug Testing and Analysis. doi:10.1002/dta.2237. PMID 28670781.
  3. ^ Mogler L, Wilde M, Huppertz LM, Weinfurtner G, Franz F, Auwärter V (January 2018). “Phase I metabolism of the recently emerged synthetic cannabinoid CUMYL-PEGACLONE and detection in human urine samples”. Drug Testing and Analysis. doi:10.1002/dta.2352. PMID 29314750.
  4. ^ ‹See Tfd›WO application 2001058869, ‹See Tfd›Leftheris K, Zhao, R, Chen BC, Kiener P, Wu H, Pandit C, Chennagiri R, Wrobleski S, Chen P, Hynes j, Longphre M, Norris D, Spergel S, Tokarski J, ”Cannabinoid Receptor Modulators, Their Processes of Preparation, and Use of Cannabinoid Receptor Modulators in Treating Respiratory and Non-Respiratory Diseases”, published 16 AUGUST 2001, assigned to Bristol-Myers Squibb Company 
  5. ^ Wrobleski ST, Chen P, Hynes J, Lin S, Norris DJ, Pandit CR, Spergel S, Wu H, Tokarski JS, Chen X, Gillooly KM, Kiener PA, McIntyre KW, Patil-Koota V, Shuster DJ, Turk LA, Yang G, Leftheris K (May 2003). “Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties”. Journal of Medicinal Chemistry. 46 (11): 2110–6. doi:10.1021/jm020329q. PMID 12747783.