Velneperit structure.png
Clinical data
ATC code
  • None
CAS Number
PubChem CID
Chemical and physical data
Molar mass407.451 g/mol g·mol−1
3D model (JSmol)

Velneperit (S-2367) is a drug developed by Shionogi, which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y5. It has anorectic effects and was developed as a possible treatment for obesity, but was discontinued from further development after disappointing results in Phase II clinical trials. However it was still considered a successful proof of concept of the potential of Y5 receptor antagonists as possible anti-obesity agents in future.[1][2][3]


  1. ^ Yukioka H. A potent and selective neuropeptide Y Y5-receptor antagonist, S-2367, as an anti-obesity agent. (Japanese). Nihon Yakurigaku Zasshi. 2010 Nov;136(5):270-4. PMID 21079365
  2. ^ Oda S, et al. Development of an Optimized Synthetic and Purification Process of S-2367 (Velneperit), a Novel Neuropeptide Y (NPY) Y5 Receptor Antagonist. Org. Process Res. Dev. 2015; 19(4):531–536. doi: 10.1021/acs.oprd.5b00023
  3. ^ George M, Rajaram M, Shanmugam E. New and emerging drug molecules against obesity. J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):65-76. doi: 10.1177/1074248413501017 PMID 24064009