In neuropsychopharmacology, uncoupling, also known as decoupling, is the process of receptor- or ligand-binding sites or domains becoming separated, moving alignments and/or becoming internalised as a result of drug tolerance resulting from prolonged exposure to bioavailable psychoactive substances or toxins.[1][2]
References[edit]
- ^ Mize, Amy L; Alpher, Richard H. "Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17(beta)-estradiol in vitro requires protein kinases A and C". Neuroendocrinology – via ProQuest.
- ^ Ganguly, Prabarna; Holland, Freedom H; Brenhouse, Heather C. "Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress". Neuropsychopharmacology.