Protein coding gene in Humans
T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene , which was initially named HOX11 .[5] [6] [7] [8] [9]
Interactions [ edit ] TLX1 has been shown to interact with PPP1CC ,[10] PPP2CB [10] PPP2CA .[10]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000107807 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025215 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science . 253 (5015): 79–82. Bibcode :1991Sci...253...79H . doi :10.1126/science.1676542 . PMID 1676542 . ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics . 7 (3): 460. doi :10.1016/0888-7543(90)90186-X . PMID 1973146 . ^ "Entrez Gene: TLX1 T-cell leukemia homeobox 1" .^ Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24" . Proceedings of the National Academy of Sciences of the United States of America . 88 (20): 8900–4. Bibcode :1991PNAS...88.8900K . doi :10.1073/pnas.88.20.8900 PMC 52618 PMID 1681546 . ^ Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)" . Blood . 78 (11): 2996–3003. doi :10.1182/blood.V78.11.2996.2996 PMID 1683261 . ^ a b c Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature . 385 (6615): 454–8. Bibcode :1997Natur.385..454K . doi :10.1038/385454a0 . PMID 9009195 . S2CID 608633 .
Further reading [ edit ]
Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma . 39 (3–4): 241–56. doi :10.3109/10428190009065824 . PMID 11342305 . S2CID 27407074 . Lu M, Zhang N, Ho AD (Jul 1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene . 7 (7): 1325–30. PMID 1352396 . Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24" . Proceedings of the National Academy of Sciences of the United States of America . 88 (20): 8900–4. Bibcode :1991PNAS...88.8900K . doi :10.1073/pnas.88.20.8900 PMC 52618 PMID 1681546 . Lu M, Gong ZY, Shen WF, Ho AD (Oct 1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein" . The EMBO Journal . 10 (10): 2905–10. doi :10.1002/j.1460-2075.1991.tb07840.x . PMC 453003 PMID 1717256 . Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH (Sep 1995). "The Hox11 gene is essential for cell survival during spleen development". Development . 121 (9): 2909–15. doi :10.1242/dev.121.9.2909 . PMID 7555717 . Dear TN, Sanchez-Garcia I, Rabbitts TH (May 1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes" . Proceedings of the National Academy of Sciences of the United States of America . 90 (10): 4431–5. Bibcode :1993PNAS...90.4431D . doi :10.1073/pnas.90.10.4431 PMC 46525 PMID 8099440 . Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature . 385 (6615): 454–8. Bibcode :1997Natur.385..454K . doi :10.1038/385454a0 . PMID 9009195 . S2CID 608633 . Brake RL, Kees UR, Watt PM (Oct 1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene" . Oncogene . 17 (14): 1787–95. doi :10.1038/sj.onc.1202078 PMID 9778044 . Zhang N, Shen W, Hawley RG, Lu M (Apr 1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization" . Oncogene . 18 (13): 2273–9. doi :10.1038/sj.onc.1202545 PMID 10327073 . Watt PM, Ranford PR, Kees UR (Jun 1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene . 234 (1): 169–76. doi :10.1016/S0378-1119(99)00157-2 . PMID 10393251 . Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications . 294 (1): 23–34. doi :10.1016/S0006-291X(02)00426-6 . PMID 12054735 . Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (Apr 2002). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Sequence . 13 (2): 77–83. doi :10.1080/10425170290029981 . PMID 12180349 . S2CID 38713800 . Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N (Jan 2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951" . Blood . 103 (2): 442–50. doi :10.1182/blood-2003-05-1495 PMID 14504110 . Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR (Dec 2004). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes, Chromosomes & Cancer . 41 (4): 309–20. doi :10.1002/gcc.20104 . PMID 15384172 . S2CID 19475690 . Riz I, Hawley RG (Aug 2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia" . Oncogene . 24 (36): 5561–75. doi :10.1038/sj.onc.1208727 . PMC 2408753 PMID 15897879 . Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK (Feb 2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells" . Leukemia . 20 (2): 304–12. doi :10.1038/sj.leu.2404071 PMID 16357834 . Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice" . Oncogene . 25 (18): 2575–87. doi :10.1038/sj.onc.1209285 PMID 16407851 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
