Protein-coding gene in the species Homo sapiens
Transducin (beta)-like 1X-linked , also known as TBL1X , is a protein which in humans is encoded by the TBL1X gene .[5]
Function [ edit ] The protein encoded by this gene has sequence similarity with members of the WD40 repeat -containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction , RNA processing, gene regulation , vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.[5]
Interactions [ edit ] TBL1X has been shown to interact with:
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000101849 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025246 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: TBL1X transducin (beta)-like 1X-linked" .^ a b c Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2" . Mol. Cell . 9 (3): 611–23. doi :10.1016/s1097-2765(02)00468-9 PMID 11931768 . ^ a b c Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness" . Genes Dev . 14 (9): 1048–57. doi :10.1101/gad.14.9.1048 . PMC 316569 PMID 10809664 . ^ a b Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1" . EMBO J . 22 (6): 1336–46. doi :10.1093/emboj/cdg120 . PMC 151047 PMID 12628926 . ^ a b Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3" . EMBO J . 19 (16): 4342–50. doi :10.1093/emboj/19.16.4342 . PMC 302030 PMID 10944117 . ^ Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (December 2002). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex" . Genes Dev . 16 (24): 3130–5. doi :10.1101/gad.1037502 . PMC 187500 PMID 12502735 .
Further reading [ edit ]
Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G (1999). "X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats" . Am. J. Hum. Genet . 64 (6): 1604–16. doi :10.1086/302408 . PMC 1377903 PMID 10330347 . Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness" . Genes Dev . 14 (9): 1048–57. doi :10.1101/gad.14.9.1048 . PMC 316569 PMID 10809664 . Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3" . EMBO J . 19 (16): 4342–50. doi :10.1093/emboj/19.16.4342 . PMC 302030 PMID 10944117 . Matsuzawa SI, Reed JC (2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses" . Mol. Cell . 7 (5): 915–26. doi :10.1016/S1097-2765(01)00242-8 PMID 11389839 . Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2" . Mol. Cell . 9 (3): 611–23. doi :10.1016/S1097-2765(02)00468-9 PMID 11931768 . Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1" . EMBO J . 22 (6): 1336–46. doi :10.1093/emboj/cdg120 . PMC 151047 PMID 12628926 . Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso" . Mol. Cell . 12 (3): 723–34. doi :10.1016/j.molcel.2003.08.008 PMID 14527417 . Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG (2004). "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors" . Cell . 116 (4): 511–26. doi :10.1016/S0092-8674(04)00133-3 PMID 14980219 . S2CID 18807923 . Yoon HG, Choi Y, Cole PA, Wong J (2005). "Reading and function of a histone code involved in targeting corepressor complexes for repression" . Mol. Cell. Biol . 25 (1): 324–35. doi :10.1128/MCB.25.1.324-335.2005 . PMC 538779 PMID 15601853 . Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O (2005). "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization" . Cell Cycle . 4 (11): 1632–40. doi :10.4161/cc.4.11.2151 PMID 16258276 .
