Protein-coding gene in humans
RIPK2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C8B , 2N7Z , 5AR3 , 5AR2 , 5AR7 , 5AR8 , 5AR5 , 5AR4 , 2N83 , 5J7B , 5J79
Identifiers Aliases RIPK2 External IDs OMIM : 603455 MGI : 1891456 HomoloGene : 37856 GeneCards : RIPK2 EC number 2.7.10.2 Wikidata
Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene .[5] [6] [7]
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.[7]
Interactions [ edit ] RIPK2 has been shown to interact with BIRC2 .[6] [8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000104312 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041135 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis" . J Biol Chem . 273 (20): 12296–300. doi :10.1074/jbc.273.20.12296 PMID 9575181 . ^ a b Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1" . Curr Biol . 8 (15): 885–8. Bibcode :1998CBio....8..885T . doi :10.1016/S0960-9822(07)00352-1 PMID 9705938 . S2CID 1235278 . ^ a b "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2" .^ McCarthy JV, Ni J, Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase" . J. Biol. Chem . 273 (27). UNITED STATES: 16968–75. doi :10.1074/jbc.273.27.16968 ISSN 0021-9258 . PMID 9642260 .
Further reading [ edit ]
Medzhitov R, Janeway C (2000). "Innate immune recognition: mechanisms and pathways". Immunol. Rev . 173 : 89–97. doi :10.1034/j.1600-065X.2000.917309.x . PMID 10719670 . S2CID 20844121 . Dufner A, Mak TW (2006). "CARD tricks: controlling the interactions of CARD6 with RICK and microtubules" . Cell Cycle . 5 (8): 797–800. doi :10.4161/cc.5.8.2635 PMID 16582588 . McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase" . J. Biol. Chem . 273 (27): 16968–75. doi :10.1074/jbc.273.27.16968 PMID 9642260 . Bertin J, Nir WJ, Fischer CM, et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB" . J. Biol. Chem . 274 (19): 12955–8. doi :10.1074/jbc.274.19.12955 PMID 10224040 . Inohara N, Koseki T, del Peso L, et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB" . J. Biol. Chem . 274 (21): 14560–7. doi :10.1074/jbc.274.21.14560 PMID 10329646 . Navas TA, Baldwin DT, Stewart TA (1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase" . J. Biol. Chem . 274 (47): 33684–90. doi :10.1074/jbc.274.47.33684 PMID 10559258 . Inohara N, Koseki T, Lin J, et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways" . J. Biol. Chem . 275 (36): 27823–31. doi :10.1074/jbc.M003415200 PMID 10880512 . Ogura Y, Inohara N, Benito A, et al. (2001). "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB" . J. Biol. Chem . 276 (7): 4812–8. doi :10.1074/jbc.M008072200 PMID 11087742 . Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing" . J. Biol. Chem . 276 (37): 34495–500. doi :10.1074/jbc.M101415200 PMID 11432859 . Khursigara G, Bertin J, Yano H, et al. (2001). "A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2" . J. Neurosci . 21 (16): 5854–63. doi :10.1523/JNEUROSCI.21-16-05854.2001 PMC 6763175 PMID 11487608 . Andersson L, Scharin Tang M (2015). "Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia" . Cardiovasc. Res . 107 (4): 478–86. doi :10.1093/cvr/cvv186 PMID 26130752 . Druilhe A, Srinivasula SM, Razmara M, et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins" . Cell Death Differ . 8 (6): 649–57. doi :10.1038/sj.cdd.4400881 PMID 11536016 . Chin AI, Dempsey PW, Bruhn K, et al. (2002). "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses". Nature . 416 (6877): 190–4. Bibcode :2002Natur.416..190C . doi :10.1038/416190a . PMID 11894097 . S2CID 4405035 . Kobayashi K, Inohara N, Hernandez LD, et al. (2002). "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems" (PDF) . Nature . 416 (6877): 194–9. Bibcode :2002Natur.416..194K . doi :10.1038/416194a . hdl :2027.42/62842 PMID 11894098 . S2CID 4363636 . Munz B, Hildt E, Springer ML, Blau HM (2002). "RIP2, a Checkpoint in Myogenic Differentiation" . Mol. Cell. Biol . 22 (16): 5879–86. doi :10.1128/MCB.22.16.5879-5886.2002 . PMC 133983 PMID 12138198 . Yoo NJ, Park WS, Kim SY, et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochem. Biophys. Res. Commun . 299 (4): 652–8. doi :10.1016/S0006-291X(02)02714-6 . PMID 12459189 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Chen YR, Clark AC (2003). "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK". Biochemistry . 42 (20): 6310–20. doi :10.1021/bi0340752 . PMID 12755636 .
