THC Science

RGS14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JNU, 2OM2, 2XNS, 3ONW, 3QI2
Identifiers
Aliases	RGS14, regulator of G protein signaling 14
External IDs	OMIM: 602513 MGI: 1859709 HomoloGene: 4735 GeneCards: RGS14
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,372,596 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,532,500 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	10636
	51791
	ENSG00000169220
	ENSMUSG00000052087
	O43566
	P97492
	NM_006480; NM_001366617; NM_001366618
	NM_016758; NM_001360714
	NP_006471; NP_001353546; NP_001353547
	NP_058038; NP_001347643
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.^[5]

Function[edit]

RGS14 is a member of the regulator of G protein signalling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[5]

Increasing the expression of the RGS14 protein in the V2 secondary visual cortex of mice promotes the conversion of short-term to long-term object-recognition memory.^[6] Conversely RGS14 is enriched in CA2 pyramidal neurons and suppresses synaptic plasticity of these synapses and hippocampal-based learning and memory.^[7]

Interactions[edit]

RGS14 has been shown to interact with:

GNAI1^[8]^[9]^[10]^[11] and
GNAI3.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RGS14 regulator of G-protein signalling 14".
^
López-Aranda MF, López-Téllez JF, Navarro-Lobato I, Masmudi-Martín M, Gutiérrez A, Khan ZU (July 2009). "Role of layer 6 of V2 visual cortex in object-recognition memory". Science. 325 (5936): 87–9. Bibcode:2009Sci...325...87L. doi:10.1126/science.1170869. PMID 19574389. S2CID 23990759.
- Annalee Newitz (July 2, 2009). "A Drug That Could Give You Perfect Visual Memory". io9.
^
Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR (September 2010). "RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory". Proc Natl Acad Sci U S A. 107 (39): 16994–8. Bibcode:2010PNAS..10716994L. doi:10.1073/pnas.1005362107. PMC 2947872. PMID 20837545.
- "Gene limits learning and memory in mice". MedicalDaily. 18 September 2010. Archived from the original on 2010-09-20.
^ ^a ^b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
^ Hollinger S, Taylor JB, Goldman EH, Hepler JR (December 2001). "RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain". J. Neurochem. 79 (5): 941–9. doi:10.1046/j.1471-4159.2001.00629.x. PMID 11739605. S2CID 22913974.
^ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (April 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. Bibcode:2002Natur.416..878K. doi:10.1038/416878a. PMID 11976690. S2CID 4406208.
^ Shu FJ, Ramineni S, Amyot W, Hepler JR (January 2007). "Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization". Cell. Signal. 19 (1): 163–76. doi:10.1016/j.cellsig.2006.06.002. PMID 16870394.

External links[edit]

Overview of all the structural information available in the PDB for UniProt: O43566 (Regulator of G-protein signaling 14) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169220 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052087 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RGS14 regulator of G-protein signalling 14".

[pmid19574389-6] López-Aranda MF, López-Téllez JF, Navarro-Lobato I, Masmudi-Martín M, Gutiérrez A, Khan ZU (July 2009). "Role of layer 6 of V2 visual cortex in object-recognition memory". Science. 325 (5936): 87–9. Bibcode:2009Sci...325...87L. doi:10.1126/science.1170869. PMID 19574389. S2CID 23990759.
Annalee Newitz (July 2, 2009). "A Drug That Could Give You Perfect Visual Memory". io9.

[7] Annalee Newitz (July 2, 2009). "A Drug That Could Give You Perfect Visual Memory". io9.

[pmid20837545-7] Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR (September 2010). "RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory". Proc Natl Acad Sci U S A. 107 (39): 16994–8. Bibcode:2010PNAS..10716994L. doi:10.1073/pnas.1005362107. PMC 2947872. PMID 20837545.
"Gene limits learning and memory in mice". MedicalDaily. 18 September 2010. Archived from the original on 2010-09-20.

[9] "Gene limits learning and memory in mice". MedicalDaily. 18 September 2010. Archived from the original on 2010-09-20.

[pmid11387333-8] Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.

[pmid11739605-9] Hollinger S, Taylor JB, Goldman EH, Hepler JR (December 2001). "RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain". J. Neurochem. 79 (5): 941–9. doi:10.1046/j.1471-4159.2001.00629.x. PMID 11739605. S2CID 22913974.

[pmid11976690-10] Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (April 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. Bibcode:2002Natur.416..878K. doi:10.1038/416878a. PMID 11976690. S2CID 4406208.

[pmid16870394-11] Shu FJ, Ramineni S, Amyot W, Hepler JR (January 2007). "Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization". Cell. Signal. 19 (1): 163–76. doi:10.1016/j.cellsig.2006.06.002. PMID 16870394.

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