THC Science

PSKH1
Identifiers
Aliases	PSKH1, protein serine kinase H1
External IDs	OMIM: 177015 MGI: 3528383 HomoloGene: 48461 GeneCards: PSKH1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,929,676 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,658,410 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	5681
	244631
	ENSG00000159792
	ENSMUSG00000048310
	P11801
	Q91YA2
	NM_006742
	NM_173432
	NP_006733
	NP_775608
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.^[5]^[6]

Interactions[edit]

PSKH1 has been shown to interact with CDC6.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159792 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048310 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (February 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
^ "Entrez Gene: PSKH1 protein serine kinase H1".
^ Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.

Hanks SK (1987). "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family". Proc. Natl. Acad. Sci. U.S.A. 84 (2): 388–92. Bibcode:1987PNAS...84..388H. doi:10.1073/pnas.84.2.388. PMC 304212. PMID 2948189.
Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.
Amarzguioui M, Brede G, Babaie E, Grotli M, Sproat B, Prydz H (2000). "Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes". Nucleic Acids Res. 28 (21): 4113–24. doi:10.1093/nar/28.21.4113. PMC 113158. PMID 11058107.
Brede G, Solheim J, Tröen G, Prydz H (2001). "Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization". Genomics. 70 (1): 82–92. doi:10.1006/geno.2000.6365. PMID 11087665.
Brede G, Solheim J, Prydz H (2002). "PSKH1, a novel splice factor compartment-associated serine kinase". Nucleic Acids Res. 30 (23): 5301–9. doi:10.1093/nar/gkf648. PMC 137962. PMID 12466556.
Brede G, Solheim J, Stang E, Prydz H (2004). "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus". Exp. Cell Res. 291 (2): 299–312. doi:10.1016/j.yexcr.2003.07.009. PMID 14644153.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)