THC Science

PRPF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	PRPF6, ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6, pre-mRNA processing factor 6
External IDs	OMIM: 613979 MGI: 1922946 HomoloGene: 5368 GeneCards: PRPF6
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,033,100 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,297,453 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	24148
	68879
	ENSG00000101161
	ENSMUSG00000002455
	O94906
	Q91YR7
	NM_012469
	NM_133701
	NP_036601
	NP_598462
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.^[5]^[6]^[7]

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.^[7]

Interactions[edit]

PRPF6 has been shown to interact with TXNL4B,^[8] ARAF^[9]^[10] and Androgen receptor.^[11]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101161 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002455 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546.
^ Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
^ ^a ^b "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)".
^ Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. 279 (31). United States: 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.
^ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2). United States: 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
^ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13). UNITED STATES: 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612.
^ Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33). United States: 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yuryev A, Ono M, Goff SA, et al. (2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Zhao Y, Goto K, Saitoh M, et al. (2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. PMID 12039962.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
Goto K, Zhao Y, Saito M, et al. (2003). "Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments". J. Steroid Biochem. Mol. Biol. 85 (2–5): 201–8. doi:10.1016/S0960-0760(03)00196-1. PMID 12943705. S2CID 46683850.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Sun X, Zhang H, Wang D, et al. (2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID 15161931.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
Batsché E, Yaniv M, Muchardt C (2006). "The human SWI/SNF subunit Brm is a regulator of alternative splicing". Nat. Struct. Mol. Biol. 13 (1): 22–9. doi:10.1038/nsmb1030. PMID 16341228. S2CID 11587161.
Fan S, Goto K, Chen G, et al. (2006). "Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor". Biochem. Biophys. Res. Commun. 341 (1): 192–201. doi:10.1016/j.bbrc.2005.12.167. PMID 16414017.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links[edit]

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101161 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002455 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10561546-5] Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546.

[pmid10788320-6] Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.

[entrez-7] "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)".

[pmid15161931-8] Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. 279 (31). United States: 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.

[pmid12620389-9] Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2). United States: 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.

[pmid10848612-10] Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13). UNITED STATES: 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612.

[pmid12039962-11] Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33). United States: 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.

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