THC Science

PPP3CB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OR9, 4ORA, 4ORC
Identifiers
Aliases	PPP3CB, CALNA2, CALNB, CNA2, PP2Bbeta, protein phosphatase 3 catalytic subunit beta
External IDs	OMIM: 114106 MGI: 107163 HomoloGene: 56429 GeneCards: PPP3CB
Gene location (Human)
Chr.	Chromosome 10 (human)
End	73,496,024 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,596,641 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	5532
	19056
	ENSG00000107758
	ENSMUSG00000021816
	P16298
	P48453
	NM_001142353; NM_001142354; NM_001289968; NM_001289969; NM_021132
	NM_008914; NM_001310426; NM_001310427
	NP_001135825; NP_001135826; NP_001276897; NP_001276898; NP_066955
	NP_001297355; NP_001297356; NP_032940
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.^[5]^[6]^[7]^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021816 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Universal protein resource accession number P16298 for "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform" at UniProt.
^ Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.
^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
^ "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

Further reading[edit]

Chen MX, Chen YH, Cohen PT (1992). "Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases". FEBS Lett. 306 (1): 54–8. doi:10.1016/0014-5793(92)80836-6. PMID 1321058. S2CID 31397906.
McPartlin AE, Barker HM, Cohen PT (1991). "Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta". Biochim. Biophys. Acta. 1088 (2): 308–10. doi:10.1016/0167-4781(91)90069-x. PMID 1848109.
Guerini D, Klee CB (1990). "Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9183–7. doi:10.1073/pnas.86.23.9183. PMC 298458. PMID 2556704.
Shibasaki F, McKeon F (1995). "Calcineurin functions in Ca(2+)-activated cell death in mammalian cells". J. Cell Biol. 131 (3): 735–43. doi:10.1083/jcb.131.3.735. PMC 2120616. PMID 7593193.
Muramatsu T, Kincaid RL (1993). "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)". Biochim. Biophys. Acta. 1178 (1): 117–20. doi:10.1016/0167-4889(93)90117-8. PMID 8392375.
Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID 8524402. S2CID 4337105.
Wang MG, Yi H, Guerini D, et al. (1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet. Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785.
Sun L, Youn HD, Loh C, et al. (1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.
Aramburu J, Garcia-Cózar F, Raghavan A, et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Mol. Cell. 1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.
Okamura H, Aramburu J, García-Rodríguez C, et al. (2000). "Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity". Mol. Cell. 6 (3): 539–50. doi:10.1016/S1097-2765(00)00053-8. PMID 11030334.
Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
Esau C, Boes M, Youn HD, et al. (2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". J. Exp. Med. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752.
Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
Banerjee A, Banks AS, Nawijn MC, et al. (2002). "Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp". J. Immunol. 168 (9): 4277–81. doi:10.4049/jimmunol.168.9.4277. PMID 11970967.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Genescà L, Aubareda A, Fuentes JJ, et al. (2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J. 374 (Pt 2): 567–75. doi:10.1042/BJ20030267. PMC 1223619. PMID 12809556.
Bell O, Gaberman E, Kilav R, et al. (2005). "The protein phosphatase calcineurin determines basal parathyroid hormone gene expression". Mol. Endocrinol. 19 (2): 516–26. doi:10.1210/me.2004-0108. PMID 15514034. S2CID 27672093.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021816 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Universal protein resource accession number P16298 for "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform" at UniProt.

[pmid1659808-6] Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.

[pmid2558868-7] Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.

[entrez-8] "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

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