Protein-coding gene in the species Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene .[5]
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.[5]
Interactions [ edit ] PFKFB2 has been shown to interact with YWHAQ .[6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000123836 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026409 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2" .^ Pozuelo Rubio M, Peggie Mark, Wong Barry H C, Morrice Nick, MacKintosh Carol (Jul 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase" . EMBO J . 22 (14). England: 3514–23. doi :10.1093/emboj/cdg363 . ISSN 0261-4189 . PMC 165633 PMID 12853467 .
Further reading [ edit ]
Rider MH, Vandamme J, Lebeau E, et al. (1992). "The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing" . Biochem. J . 285 (2): 405–11. doi :10.1042/bj2850405 . PMC 1132803 PMID 1322130 . Hilliker CE, Darville MI, Aly MS, et al. (1991). "Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization". Genomics . 10 (4): 867–73. doi :10.1016/0888-7543(91)90174-D . PMID 1655632 . Goldmuntz EA, Remmers EF, Zha H, et al. (1994). "Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5" . Mamm. Genome . 4 (11): 670–5. doi :10.1007/BF00360905 . PMID 7904197 . S2CID 1892799 . Hirata T, Kato M, Okamura N, et al. (1998). "Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines". Biochem. Biophys. Res. Commun . 242 (3): 680–4. doi :10.1006/bbrc.1997.8024 . PMID 9464277 . Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S (1998). "Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)" . Eur. J. Biochem . 254 (1): 103–10. doi :10.1046/j.1432-1327.1998.2540103.x PMID 9652401 . Hirata T, Watanabe M, Miura S, et al. (2001). "Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues" . Biosci. Biotechnol. Biochem . 64 (10): 2047–52. doi :10.1271/bbb.64.2047 PMID 11129574 . S2CID 38413244 . Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain". Brain Res. Mol. Brain Res . 87 (2): 190–5. doi :10.1016/S0169-328X(01)00014-6 . PMID 11245921 . Soejima H, Kawamoto S, Akai J, et al. (2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics . 74 (1): 115–20. doi :10.1006/geno.2001.6527 . PMID 11374908 . Baltrusch S, Lenzen S, Okar DA, et al. (2001). "Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner" . J. Biol. Chem . 276 (47): 43915–23. doi :10.1074/jbc.M105470200 PMID 11522786 . Marsin AS, Bouzin C, Bertrand L, Hue L (2002). "The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase" . J. Biol. Chem . 277 (34): 30778–83. doi :10.1074/jbc.M205213200 PMID 12065600 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Pozuelo Rubio M, Peggie M, Wong BH, et al. (2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase" . EMBO J . 22 (14): 3514–23. doi :10.1093/emboj/cdg363 . PMC 165633 PMID 12853467 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50. Bibcode :2004CBio...14.1436J . doi :10.1016/j.cub.2004.07.051 PMID 15324660 . S2CID 2371325 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 .
Glycolysis
Gluconeogenesis only
Regulatory
