THC Science

PFKFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790 MGI: 107816 HomoloGene: 105654 GeneCards: PFKFB1
Gene location (Human)
Chr.	X chromosome (human)
End	54,998,534 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	149,426,874 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	5207
	18639
	ENSG00000158571
	ENSMUSG00000025271
	P16118
	P70266
	NM_001271804; NM_001271805; NM_002625
NM_008824; NM_001374170; NM_001374171; NM_001374172; NM_001374173;
	NM_001374175
	NP_001258733; NP_001258734; NP_002616
NP_032850; NP_001361099; NP_001361100; NP_001361101; NP_001361102;
	NP_001361104
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.^[5]^[6]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158571 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025271 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
^ ^a ^b "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".