p21 activated kinases (PAKs) are members of a family of enzymes.[1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.
Members include:
- PAK1, regulating cell motility and morphology[2]
- PAK2, possibly playing a role in apoptosis[3]
- PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity[4]
- PAK4, a mediator of filopodia formation[5]
- PAK5, a mediator of filopodia formation[6]
- PAK6, involved in cytoskeleton rearrangement[7]
References[edit]
- ^ p21-Activated+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ "Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)".
- ^ "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2".
- ^ "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3".
- ^ "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4".
- ^ "PAK5 p21 (RAC1) activated kinase 5 [Homo sapiens (human)] - Gene - NCBI".
- ^ "PAK6 p21 (RAC1) activated kinase 6 [Homo sapiens (human)] - Gene - NCBI".
External links[edit]
- PAK Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine