NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas.[1] It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.[2]
In mammals there are two types of this factor:
References[edit]
- ^ Gu, Chunyan; Stein, Gretchen H.; Pan, Ning; Goebbels, Sandra; Hörnberg, Hanna; Nave, Klaus-Armin; Herrera, Pedro; White, Peter; Kaestner, Klaus H.; Sussel, Lori; Lee, Jacqueline E. (7 April 2010). "Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity". Cell Metabolism. 11 (4): 298–310. doi:10.1016/j.cmet.2010.03.006. ISSN 1550-4131. PMC 2855640. PMID 20374962.
- ^ Morrow, E.M.; Furukawa, T.; Lee, J.E.; Cepko, C.L. (1 January 1999). "NeuroD regulates multiple functions in the developing neural retina in rodent". Development. 126 (1): 23–36. doi:10.1242/dev.126.1.23. PMID 9834183. Retrieved 1 March 2022.