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| Clinical data | |
|---|---|
| Trade names | Arranon, Atriance |
| Other names | 506U78 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a607077 |
| License data |
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| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | <25% |
| Metabolism | By adenosine deaminase, to 9-β-D-arabinofuranosylguanine |
| Elimination half-life | 30 minutes (nelarabine) 3 hours (ara-G) |
| Excretion | Kidney |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.170.768 |
| Chemical and physical data | |
| Formula | C11H15N5O5 |
| Molar mass | 297.271 g·mol−1 |
| 3D model (JSmol) | |
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Nelarabine, sold under the brand names Arranon (US) and Atriance (EU), is a chemotherapy medication used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).[2][3]
Nelarabine is a prodrug of arabinosylguanine nucleotide triphosphate (araGTP), a type of purine nucleoside analog, which causes inhibition of DNA synthesis and cytotoxicity.[4] Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. In October 2005, it was approved by the FDA for acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed following treatment with at least two chemotherapy regimens.[5] It was later approved in the European Union in October 2005.[3] It is available as a generic medication.[6]
References[edit]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ a b "Arranon- nelarabine injection". DailyMed. 11 June 2020. Retrieved 4 December 2020.
- ^ a b c "Atriance EPAR". European Medicines Agency (EMA). Retrieved 4 December 2020.
- ^ "Nelarabine". Guide to Pharmacology. IUPHAR/BPS. Retrieved 21 August 2015.
- ^ Cohen MH, Johnson JR, Justice R, Pazdur R (June 2008). "FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma". The Oncologist. 13 (6): 709–14. doi:10.1634/theoncologist.2006-0017. PMID 18586926. S2CID 23463537.
- ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
External links[edit]
- "Nelarabine". Drug Information Portal. U.S. National Library of Medicine.
- "Nelarabine". NCI Dictionary of Cancer Terms. National Cancer Institute.
- "Nelarabine". National Cancer Institute.[permanent dead link]
