THC Science

NEU4
Identifiers
Aliases	NEU4, neuraminidase 4
External IDs	OMIM: 608527 MGI: 2661364 HomoloGene: 15433 GeneCards: NEU4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,817,413 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,956,056 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	129807
	241159
	ENSG00000204099; ENSG00000277926
	ENSMUSG00000034000
	Q8WWR8
	Q8BZL1
	NM_080741; NM_001167599; NM_001167600; NM_001167601; NM_001167602
	NM_173772; NM_001310769
NP_001161071; NP_001161072; NP_001161073; NP_001161074; NP_542779;
	NP_001161071.1; NP_001161072.1; NP_001161073.1; NP_001161074.1
	NP_001297698; NP_776133
	Wikidata
View/Edit Human	View/Edit Mouse

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.^[5]

Function[edit]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.^[5]

Interactions[edit]

Sialidase-4 has been shown to interact with phospholipid scramblase 1.^[6]

References[edit]

^ ^a ^b ^c ENSG00000277926 GRCh38: Ensembl release 89: ENSG00000204099, ENSG00000277926 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034000 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NEU4 sialidase 4".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading[edit]

Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase". Gene. 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID 14637003.
Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family". Genomics. 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103. S2CID 27379898.

[refGRCh38Ensembl-1] ENSG00000277926 GRCh38: Ensembl release 89: ENSG00000204099, ENSG00000277926 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034000 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NEU4 sialidase 4".

[pmid16189514-6] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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