|Systematic IUPAC name
(+)-Dehydroabietylamine; Amine D
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||285.475 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Leelamine (dehydroabietylamine) is a diterpene amine that has weak affinity for the cannabinoid receptors CB1 and CB2, as well as being an inhibitor of pyruvate dehydrogenase kinase. Optically active leelamine is also used as a chiral resolving agent for carboxylic acids. Leelamine has been shown to be effective against certain cancer cells, independent from its activity on CB receptors or PDK1 - it accumulates inside the acidic lysosomes leading to disruption of intracellular cholesterol transport, autophagy and endocytosis followed by cell death.
- "Leelamine - Dehydroabietylamine - Cayman Chemical". Retrieved May 20, 2013.
- US patent 3454626
- US patent 4559178
- Kuzu, O. F.; Gowda, R.; Sharma, A.; Robertson, G. P. (2014). "Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport". Molecular Cancer Therapeutics. 13 (7): 1690–703. doi:10.1158/1535-7163.MCT-13-0868. PMC 4373557. PMID 24688051.