|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||385.472 g/mol g·mol−1|
|3D model (JSmol)|
JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7nM at CB1 vs 3.3nM at CB2. It was discovered by, and named after, Dr. John W. Huffman. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany.
- Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters 2006; 16:5432-5435.
- Ernst, L.; Krüger, K.; Lindigkeit, R.; Schiebel, H. M.; Beuerle, T. (2012). “Synthetic cannabinoids in “spice-like” herbal blends: First appearance of JWH-307 and recurrence of JWH-018 on the German market”. Forensic Science International. 222 (1–3): 216–22. doi:10.1016/j.forsciint.2012.05.027. PMID 22748479.
- Kneisel, S.; Auwärter, V. (2012). “Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction”. Journal of Mass Spectrometry. 47 (7): 825–835. doi:10.1002/jms.3020. PMID 22791249.