Protein-coding gene in the species Homo sapiens
Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene .[5] [6]
The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family.[5] [7]
Interactions [ edit ] HSPA4 has been shown to interact with:
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000170606 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020361 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Fathallah DM, Cherif D, Dellagi K, Arnaout MA (Jul 1993). "Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5" . Journal of Immunology . 151 (2): 810–3. doi :10.4049/jimmunol.151.2.810 PMID 8335910 . ^ "Entrez Gene: HSPA4 heat shock 70kDa protein 4" .^ Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J (Apr 1997). "Cloning of apg-2 encoding a novel member of heat shock protein 110 family". Gene . 189 (1): 19–24. doi :10.1016/S0378-1119(96)00807-4 . PMID 9161406 . ^ Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES (Aug 2000). "Negative regulation of the Apaf-1 apoptosome by Hsp70". Nature Cell Biology . 2 (8): 476–83. doi :10.1038/35019510 . PMID 10934467 . S2CID 20374981 . ^ a b c Oh WK, Song J (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation" . Molecules and Cells . 16 (1): 84–91. doi :10.1016/S1016-8478(23)13770-8 PMID 14503850 . ^ a b Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM (Mar 2002). "Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70" . The Journal of Biological Chemistry . 277 (11): 9590–7. doi :10.1074/jbc.M107942200 PMID 11777905 . ^ Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF (Dec 1996). "A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor" . Cell Stress & Chaperones . 1 (4): 237–50. doi :10.1379/1466-1268(1996)001<0237:apomci>2.3.co;2 (inactive 2024-04-02). PMC 376461 PMID 9222609 . {{cite journal }}: CS1 maint: DOI inactive as of April 2024 (link )^ Abravaya K, Myers MP, Murphy SP, Morimoto RI (Jul 1992). "The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression" . Genes & Development . 6 (7): 1153–64. doi :10.1101/gad.6.7.1153 PMID 1628823 . ^ Anwar A, Siegel D, Kepa JK, Ross D (Apr 2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1" . The Journal of Biological Chemistry . 277 (16): 14060–7. doi :10.1074/jbc.M111576200 PMID 11821413 . ^ Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions" . Molecular and Cellular Biology . 19 (6): 4535–45. doi :10.1128/mcb.19.6.4535 . PMC 104411 PMID 10330192 .
Further reading [ edit ]
Abravaya K, Myers MP, Murphy SP, Morimoto RI (Jul 1992). "The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression" . Genes & Development . 6 (7): 1153–64. doi :10.1101/gad.6.7.1153 PMID 1628823 . Liao J, Lowthert LA, Ghori N, Omary MB (Jan 1995). "The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner" . The Journal of Biological Chemistry . 270 (2): 915–22. doi :10.1074/jbc.270.2.915 PMID 7529764 . Furlini G, Vignoli M, Re MC, Gibellini D, Ramazzotti E, Zauli G, La Placa M (Jan 1994). "Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein" . The Journal of General Virology . 75 (1): 193–9. doi :10.1099/0022-1317-75-1-193 PMID 7906708 . Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Schulte AM, Fischer S, Sachse GE, Häfner S, Stelck S, Gassen HG (Mar 1997). "Identification and characterization of a novel hsc70-like gene in the human lung tumor cell line HS24". DNA and Cell Biology . 16 (3): 257–68. doi :10.1089/dna.1997.16.257 . PMID 9115634 . Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J (Apr 1997). "Cloning of apg-2 encoding a novel member of heat shock protein 110 family". Gene . 189 (1): 19–24. doi :10.1016/S0378-1119(96)00807-4 . PMID 9161406 . Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G (1998). "The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52". Receptors & Signal Transduction . 7 (2): 85–98. PMID 9392437 . Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI (Jul 1998). "Negative regulation of the heat shock transcriptional response by HSBP1" . Genes & Development . 12 (13): 1962–74. doi :10.1101/gad.12.13.1962 . PMC 316975 PMID 9649501 . Naylor DJ, Stines AP, Hoogenraad NJ, Høj PB (Aug 1998). "Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members" . The Journal of Biological Chemistry . 273 (33): 21169–77. doi :10.1074/jbc.273.33.21169 PMID 9694873 . Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG (Feb 1999). "The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity" . The Journal of Biological Chemistry . 274 (6): 3797–803. doi :10.1074/jbc.274.6.3797 PMID 9920933 . Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions" . Molecular and Cellular Biology . 19 (6): 4535–45. doi :10.1128/mcb.19.6.4535 . PMC 104411 PMID 10330192 . Liu H, Vuyyuru VB, Pham CD, Yang Y, Singh B (Jun 1999). "Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association" . Oncogene . 18 (23): 3461–70. doi :10.1038/sj.onc.1202699 PMID 10376524 . Nonoguchi K, Itoh K, Xue JH, Tokuchi H, Nishiyama H, Kaneko Y, Tatsumi K, Okuno H, Tomiwa K, Fujita J (Sep 1999). "Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes". Gene . 237 (1): 21–8. doi :10.1016/S0378-1119(99)00325-X . PMID 10524232 . O'Keeffe B, Fong Y, Chen D, Zhou S, Zhou Q (Jan 2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription" . The Journal of Biological Chemistry . 275 (1): 279–87. doi :10.1074/jbc.275.1.279 PMID 10617616 . Agostini I, Popov S, Li J, Dubrovsky L, Hao T, Bukrinsky M (Sep 2000). "Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex". Experimental Cell Research . 259 (2): 398–403. doi :10.1006/excr.2000.4992 . PMID 10964507 . Kim M, Jiang LH, Wilson HL, North RA, Surprenant A (Nov 2001). "Proteomic and functional evidence for a P2X7 receptor signalling complex" . The EMBO Journal . 20 (22): 6347–58. doi :10.1093/emboj/20.22.6347 . PMC 125721 PMID 11707406 . Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM (Mar 2002). "Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70" . The Journal of Biological Chemistry . 277 (11): 9590–7. doi :10.1074/jbc.M107942200 PMID 11777905 . Gurer C, Cimarelli A, Luban J (May 2002). "Specific incorporation of heat shock protein 70 family members into primate lentiviral virions" . Journal of Virology . 76 (9): 4666–70. doi :10.1128/JVI.76.9.4666-4670.2002 . PMC 155079 PMID 11932435 . Freeman BC, Yamamoto KR (Jun 2002). "Disassembly of transcriptional regulatory complexes by molecular chaperones". Science . 296 (5576): 2232–5. doi :10.1126/science.1073051 . PMID 12077419 . S2CID 8844179 .
External links [ edit ]
