EHMT1

EHMT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EHMT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, euchromatic histone lysine methyltransferase 1, EHMT1-IT1, KLEFS1
External IDs MGI: 1924933 HomoloGene: 11698 GeneCards: EHMT1
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)

Genomic location for EHMT1
Genomic location for EHMT1
Band 9q34.3 Start 137,618,963 bp[1]
End 137,870,016 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012518
NM_001109686
NM_001109687
NM_172545

RefSeq (protein)

NP_001012536
NP_001103156
NP_001103157
NP_766133

Location (UCSC) Chr 9: 137.62 – 137.87 Mb Chr 2: 24.79 – 24.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene.[5]

Function[edit]

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC– and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition.[5]

Clinical significance[edit]

Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome).[5]

References[edit]

Further reading[edit]