Chloroxine

Clinical data
Trade names	Capitrol
Other names	cloroxinum, kloroxin, chlorquinol, dichlorchinolinolum, halquinol(s)
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	none
Legal status
Legal status	US: ℞-only
Identifiers
CAS Number	773-76-2
PubChem CID	2722
ChemSpider	2621
UNII	2I8BD50I8B
ChEMBL	ChEMBL1200596
CompTox Dashboard (EPA)	DTXSID5022801
ECHA InfoCard	100.011.144
Chemical and physical data
Formula	C9H5Cl2NO
Molar mass	214.05 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1c(O)c2ncccc2c(Cl)c1
InChI InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H Key:WDFKMLRRRCGAKS-UHFFFAOYSA-N

Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s));^{[citation needed]} Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug.^[1] Oral formulations (under trade name such as Endiaron^[2]) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis.,^[3] as used in shampoos (Capitrol) and dermal creams like (Valpeda, Triaderm).

Mechanism of action[edit]

Chloroxine has bacteriostatic, fungistatic, and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella, and Trichomonads.^{[citation needed]}

Adverse effects[edit]

Rarely occurs, but may cause nausea and vomiting associated with oral administration. It may also cause skin irritation.^{[citation needed]}

Pregnancy and lactation[edit]

The FDA lists chloroxine in Pregnancy Category C (risk cannot be ruled out) because no pregnancy studies on the medication have been performed with animals or humans. For this reason, use of chloroxine oral or topical during pregnancy or when breast-feeding is not recommended.^[4]

History[edit]

Chloroxine was first prepared in 1888 by A. Hebebrand.^{[citation needed]}

References[edit]