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Balofloxacin
Clinical data
ATC code
  • none
Identifiers
  • 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H24FN3O4
Molar mass389.427 g·mol−1
3D model (JSmol)
  • CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
  • InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27) checkY
  • Key:MGQLHRYJBWGORO-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Balofloxacin (INN) is a fluoroquinolone antibiotic. It is sold under the brand name Q-Roxin in Korea, and under various names in India.[1] It is not approved by the FDA for use in the United States.

Pharmacodynamics[edit]

Balofloxacin is a fluoroquinolone that has a broad spectrum in vitro activity against a wide range of Gram-positive and Gram-negative bacteria, with enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae.[2] It functions by inhibiting the action of DNA-gyrase, preventing bacterial cells from reproducing or repairing themselves, resulting in cellular death.[3]

Side Effects[edit]

Vomiting, headache, dizziness, stomach pain, nausea, diarrhea and decreased liver function are the most common side effects. In rare cases, Balofloxacin can lead to or worsen tendinitis,[3] and muscular damage.[3]

See also[edit]

References[edit]

  1. ^ Alksne L (February 2003). "Balofloxacin Choongwae". Current Opinion in Investigational Drugs. 4 (2): 224–9. PMID 12669387.
  2. ^ "NCATS Inxight Drugs — BALOFLOXACIN". drugs.ncats.io. Retrieved 2022-07-28.
  3. ^ a b c "BALOFLOXACINhome: Uses, Side Effects and Medicines | Apollo Pharmacy". www.apollopharmacy.in. Retrieved 2022-07-28.
source: https://en.wikipedia.org/wiki/Balofloxacin

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