ATF6

ATF6
Identifiers
Aliases ATF6, ATF6A, ACHM7, activating transcription factor 6
External IDs MGI: 1926157 HomoloGene: 32015 GeneCards: ATF6
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)

Genomic location for ATF6
Genomic location for ATF6
Band 1q23.3 Start 161,766,294 bp[1]
End 161,964,070 bp[1]
RNA expression pattern
PBB GE ATF6 203952 at fs.png

PBB GE ATF6 217550 at fs.png

More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007348

NM_001081304

RefSeq (protein)

NP_031374

NP_001074773

Location (UCSC) Chr 1: 161.77 – 161.96 Mb Chr 1: 170.7 – 170.87 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[5][6][7] and is involved in the unfolded protein response.

Function[edit]

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also[edit]

Interactions[edit]

ATF6 has been shown to interact with YY1[9] and Serum response factor.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118217Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026663Ensembl, May 2017
  3. ^ “Human PubMed Reference:”.
  4. ^ “Mouse PubMed Reference:”.
  5. ^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). “Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers”. Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827.
  6. ^ a b Zhu C, Johansen FE, Prywes R (September 1997). “Interaction of ATF6 and serum response factor”. Mol. Cell. Biol. 17 (9): 4957–66. doi:10.1128/MCB.17.9.4957. PMC 232347. PMID 9271374.
  7. ^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). “Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians”. J. Clin. Endocrinol. Metab. 92 (7): 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018.
  8. ^ “Entrez Gene: ATF6 activating transcription factor 6”.
  9. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). “ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1”. Mol. Cell. Biol. 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. PMC 85959. PMID 10866666.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.