Research

Adverse Structural and Functional Effects of Marijuana on the Brain: Evidence Reviewed

Article Outline Narrative review Historical perspective Terminology Cellular drug actions Disputed antiepileptic effects Causal agent in psychosis Cannabis use and cognitive impairment Cannabis use worsens neuropsychologic function in people with multiple sclerosis Cannabis-associated subcortical nuclear gray matter structural changes—neuroimaging Safety concerns Patient Description Discussion Cannabis-associated neuropathology Correlates of cannabis-associated microstructural white matter pathology Is the… read more »

Support for Marijuana Legalization and Predictors of Intentions to Use Marijuana More Often in Response to Legalization Among U.S. Young Adults

Amy M. Cohn, Amanda L. Johnson, Shyanika W. Rose, Jessica M. Rath & Andrea C. Villanti Pages 203-213 | Published online: 19 Oct 2016 ABSTRACT Background: As of 2015, more than half of U.S. states have legalized, medicalized, or decriminalized marijuana. Objective: This study examined the prevalence and correlates of support for marijuana legalization in… read more »

Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture

Liting Deng, Lindsay Ng, Tatsuya Ozawa and Nephi Stella Journal of Pharmacology and Experimental Therapeutics November 7, 2016, jpet.116.236968; DOI: https://doi.org/10.1124/jpet.116.236968  Abstract Evidence suggests that the non-psychotropic cannabis-derived compound, cannabidiol (CBD), has anti-neoplastic activity in multiple types of cancers, including glioblastoma multiforme (GBM). DNA-damaging agents remain the main standard of care treatment available for patients… read more »

Cannabidiol: State of the art and new challenges for therapeutic applications.

Pisanti S1, Malfitano AM2, Ciaglia E2, Lamberti A2, Ranieri R2, Cuomo G2, Abate M2, Faggiana G2, Proto MC3, Fiore D3, Laezza C4, Bifulco M5. Author information 1Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Italy. Electronic address: spisanti@unisa.it. 2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Italy…. read more »

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

Luciano De Petrocellis, Vittorio Vellani, Aniello Schiano-Moriello, Pietro Marini, Pier Cosimo Magherini, Pierangelo Orlando and Vincenzo Di Marzo Journal of Pharmacology and Experimental Therapeutics June 2008, 325 (3) 1007-1015; DOI: https://doi.org/10.1124/jpet.107.134809 Abstract The plant cannabinoids (phytocannabinoids), cannabidiol (CBD), and Δ9-tetrahydrocannabinol (THC) were previously shown to activate transient receptor potential channels of both vanilloid type 1… read more »

Medical marijuana use in head and neck squamous cell carcinoma patients treated with radiotherapy

Elliott DA1, Nabavizadeh N2, Romer JL2, Chen Y3, Holland JM2. 1Department of Radiation Medicine, Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA. elliotda@ohsu.edu. 2Department of Radiation Medicine, Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA…. read more »

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation

Yadvinder Singha,* and Chamandeep Balib Author information ► Copyright and License information ► Abstract Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination chemotherapy, with a remission state after 5 years of 94% in children and 30–40% in adults. To establish how aggressive the disease… read more »

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression

Robert J. McKallip, Wentao Jia, Jerome Schlomer, James W. Warren, Prakash S. Nagarkatti and Mitzi Nagarkatti Molecular Pharmacology September 2006, 70 (3) 897-908; DOI: https://doi.org/10.1124/mol.106.023937 Abstract In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells. Exposure of leukemia cells to cannabidiol led to… read more »

Cannabis

Container for Providing Aromatic Sampling and Visualization of Contents WT Smith, CA Smith – US Patent 20,160,318,672, 2016 – freepatentsonline.com 5 days ago – Aspects of the present invention disclose and describe a container for displaying, visualizing, and aroma sampling botanical materials—such as tea, <i>cannabis</i>, and the like including a container. …   Saying no… read more »

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