Purple Gang can refer to:

• The Purple Gang, Jewish American bootleggers and hijackers in Detroit during the 1920s
• East Harlem Purple Gang, Italian American gang of drug dealers and hitmen
• The Purple Gang (film), a 1960 American crime film
• The Purple Gang (American band), a 1960s garage/psychedelic band
• The Purple Gang (British band), British rock band active intermittently since the 1960s
• Purple People Eaters, defensive line of the Minnesota Vikings from the late 1960s to the late 1970s