Sophia Smith may refer to:

• Sophia Smith (soccer, born 2000), American footballer
• Sophia Smith (footballer, born 1978), American-Greek footballer
• Sophia Smith (Smith College) (1796–1870), founder of Smith College
• Sophia Smith Collection, repository of manuscripts, photographs, periodicals and other primary sources in women's history

See also[edit]

• Sofia Tekela-Smith (born 1960), New Zealand artist
• Sophie Smith (born 1986), Australian water polo player
• Sophie Smith (journalist) (born 1986), Australian journalist