Meg is hired by a man to babysit his pre-teen son Ralph for one night in Room 104. She is initially amused when Ralph warns her that "Ralphie", a bad boy, is locked in the bathroom, and that they need to keep quiet so they do not wake Ralphie. Thinking he is an imaginary friend, Meg at first humors Ralph, but becomes scared after Ralph goes into the bathroom dressed normally but returns in only underwear and a towel as a cape calling himself Ralphie; he attacks her. Ralphie goes back to the bathroom and Ralph returns dressed normally. Ralph tells Meg that he and his dad say his mother hanged herself but he says the true story is Ralphie killed her. After talking too loudly, Ralph says Ralphie has woken again. This time both Ralph and Ralphie emerge from the bathroom at the same time. Ralphie suffocates Ralph to death on the bed and then attacks her on the floor. Meg overpowers Ralphie and strangles him to death. Ralph's father returns to find Meg strangling Ralph and when she looks to the bed sees no body there and sees the body she was strangling was dressed as Ralph.

A pizza delivery boy is drawn into a couple's bizarre sex game where the wife attempts to seduce the delivery boy while the husband goes to get cash to pay for the pizza. She leaves when the husband returns and he accuses delivery boy of having sex with the wife and ties up the delivery boy. The wife returns and the couple have sex, apparently aroused by their fight and by having someone watch. After sex the delivery boy is seen wearing a suit, he offers the couple pointers on their performance and pays them, the whole situation having been one of the "delivery boy" auditioning actors to perform immersive sexual role play for his voyeuristic clients.

A spiritually-hungry woman is visited by a cult priest. She remembers that when she was a child, a boy showed her his penis and she hit it with a rock.

A 42-year-old guest, whose wife wants to split up with him, seeks advice from the ghost of his college best friend who accidentally drowned in his early twenties.

In 1997, a young Indian man desperately tries to teach his mother, over the phone, how to use his laptop to send a copy of the novel he has been writing. She accidentally deletes his novel, so he tells her to take it to a computer shop so that the staff can try to retrieve it.

An episode told through interpretive dance, with very little dialogue. A middle-aged maid and former call girl reconnects with her younger self.

Two Mormons test their faith and their attraction to each other.

In 1969, the sole (apparent) survivor of a plane crash finds herself in the room, covered in mud, cuts and bruises. She contemplates whether to go back to her old life with her husband.

An alcoholic Croatian retired tennis player forms a bond with a housekeeper when he reveals memories of his tortured past growing up in war torn Croatia during the early 1990s while she in turn reveals her status as an undocumented immigrant.

A young man planning to detonate an explosive at a political convention is interrupted by an air conditioning repairman, causing him to reconsider his plan.

Two female MMA fighters collude to earn a bigger payout by throwing their upcoming match. They engage in a private competition to determine who will win the fight.

An elderly couple relive their first night together.

A young woman celebrates her birthday with her friends, but things go downhill when her sister arrives unexpectedly.

A man confronts his former third-grade teacher, seeking a confession about their shared past.

An eccentric Russian political technologist arranges a first date with a veterinary nurse after meeting her via the internet.

Two strangers meet to fulfill a mutual fantasy, but are interrupted by a suspicious police officer. This episode is based on true events.^[25]

A sickly woman seeks comfort from a disembodied voice that claims to live inside the walls.

Presented as a musical, a man attempts to piece together his memories of the previous night and the woman he met.

A couple experiences difficulties while recording a video – which they plan to show their future child – of their attempts to conceive.

A young woman finds herself unable to escape a series of increasingly disturbing nightmares, some involving her mother.

A widow brings her young daughter to Room 104 to help the girl cope with her father's death.

An apparent android attempts to convince a skeptical reporter of the true nature of both of their existences.

A pool shark and his disillusioned cousin clash over their conflicting views of the hustling game.

A playwright searching for inspiration asks her younger self to reenact the events of a harrowing night from her college years.

Decades in the past, a brother and sister have a tense meeting regarding the development of the hotel that will contain Room 104, complicated by the arrival of a demonic transient.

The irresponsible caretaker of a gorilla meets with a professional who wants to buy the animal from him, but things do not go as planned.

A man with a mysterious skin condition records a series of increasingly revelatory video messages for his doctor.

Following an apocalyptic event, a traumatized teenage girl and a psychically gifted scavenger find common ground in their struggle for the future.

A man's patience is tested as he must contend with his coworker's chronic sleepwalking problem.

A tormented singer-songwriter grapples with her own insecurities - and those of her ex-girlfriend - while attempting to create a new song.

A documentary about real-life father and son artists who, invited to use the Room 104 set as a canvas, discuss the personal struggles in their past and the nuances of their craft.

A dying man with unique abilities attempts to settle his affairs with his daughter, who was reluctant to learn his powers, and his son, who misused them.

Left alone, a teenage girl makes prank calls to entertain herself, but one takes a very dark turn spurred on by her alternate personality.

Two actors who co-created a 1970s horror television series reunite and discuss their falling out, but when old tensions resurface, the show proves to be much more than mere fiction.

Fifty years after a woman sells her soul to the devil to live a rebellious rock-and-roll lifestyle, she strikes a mutually beneficial deal with his disgruntled assistant.

When exposure to a mysterious plant specimen transforms Room 104 into a lush jungle ecosystem, a scientist tries desperately to preserve the phenomena within.